The immunological function of patients with malignant tumors could be suppressed during the perioperative period. to T5, the mean arterial pressure (MAP) and heart rate (HR), the intraoperative consumption of propofol and remifentanil, the incidence of hypoxemia, postoperative nausea and vomiting (PONV), and CFM-2 the length of hospital stay. The quantities of NK cells were decreased in group sham TEAS after intubation compared to that in group TEAS, while the quantities of NK cells in group TEAS were similar at T0 to T5. Meanwhile, the quantities of NK cells in group sham TEAS at T1 (= .012), T2 ( .001), T3 (= CFM-2 .027), T4 (= .045), and T5 (= .021) were lower than those in group TEAS. In group TEAS, the serum levels of TNF- were lower at T1 to T5, while the levels of IL-6 were lower at T2 to T5. Furthermore, the intraoperative MAP and HR were more stable, the total propofol and remifentanil consumptions were lower, and the length of hospital stay was shorter than those in group sham TEAS. The application of TEAS can effectively reverse the decrease in NK cells, decrease the serum levels of TNF- and IL-6, maintain hemodynamic stability during the perioperative period, decrease the consumption of propofol and remifentanil, and shorten the length of the hospital stay. sensation was used to establish the efficacy of the acupoint stimulation. For patients in group sham TEAS, electrode tabs were placed on the bilateral BL13, L14, and ST36 similar to patients in group TEAS, but electrical stimulation was not initiated. The electrodes were well protected from detaching during the operation. The TAES intervention was performed by a research nurse who was a qualified member of the research team and then verified by 2 traditional Chinese medicine physicians. Throughout the trial, participants were treated separately to prevent communication. All patients were provided 100% oxygen for 3 minutes before induction. Anesthesia induction was initiated by experienced anesthesiologists with 0.1 mg/kg midazolam, 4 g/kg fentanyl, 0.4 mg/kg etomidate, and 0.6 mg/kg rocuronium. A left double-lumen endotracheal tube (Mallinckrodt; Covidien, Manseld, Massachusetts) was used for intubation, and its correct position was confirmed by fiberoptic bronchoscopy. All the patients received propofol and remifentanil, controlled by the same closed-loop automated system, during the induction and maintenance of general anesthesia. The BIS values were maintained between 40 and 50, with the intermittent addition of cis-atracurium, to ensure the progress of the surgery. All anesthetics were discontinued at the end of the surgery. No anti-inflammatory drugs were administered CFM-2 after surgery. All participants were transferred to the postanesthesia care unit (PACU) after surgery and then escorted back to the cardiothoracic surgery ward by the anesthesia nurse after extubation. All surgeries were performed by an experienced, skilled chief surgeon who was blinded to the grouping. Patients were discharged when they met the following criteria: (1) surgical wounds were healing well without contamination; (2) pain wound score Rabbit Polyclonal to Akt was less than 3 points (assessed by the Visual Analog Scale); (3) vital signs were stable; and (4) they had no postoperative complications, such as pneumothorax, pleural effusion, and pulmonary contamination. Measurements The principal result was the levels of NK cells. For everyone sufferers, a 5-mL venous bloodstream sample was attracted through the forearm vein using a syringe formulated with heparin at thirty minutes before induction (T0), five minutes after intubation (T1), at the start of the procedure (T2), at the start from the lobectomy (T3),.