We observed no statistically significant variations in the prevalence of antibodies against additional AIV subtypes between the control group and poultry workers (Appendix Table 2). Seroconversion of Antibodies against AIVs among Poultry Workers We observed seroconversion in all AIV antigens during the study period, except the H10 subtype, which might represent a new asymptomatic AIV illness among poultry workers (Number 4, panel A). for H7N9 and H9N2 illness among poultry workers. H5N1-SH1996 (0.9, 0.2C1.5)6 (1.2, 0.2C2.1)10 (2.1, 0.8C3.4)6 (1.4, 0.3C2.5)28 (1.3, 0.8C1.8) H5N1-SC2922 (3.1, 1.8C4.4)17 (3.4, 1.8C4.9)2 (0.4, 0.1C1.5)3 (0.7, 0.1C2.0)44 (2.1, 1.5C2.7) H5N628 (4, 2.5C5.5)11 (2.2, 0.9C3.4)2 (0.4, 0.1C1.5)1 (0.2, 0C1.3)42 (2.0, 1.4C2.6) H6N122 (3.1, 1.8C4.4)21 (4.1, 2.4C5.9)5 (1, 0.1C1.9)5 (1.1, 0.4C2.6)53 (2.5, 1.8C3.2) H6N60 (0, 0C0.5)0 (0, 0C0.7)7 (1.5, 0.4C2.5)1 (0.2, 0C1.3)8 (0.4, 0.1C0.6) H7N933 (4.7, 3.1C6.3)36 (7.1, 4.9C9.4)6 (1.3, 0.3C2.2)7 (1.6, 0.4C2.8)82 (3.9, 3.0C4.7) H9N2 hr / 48 (6.9, 5.0C8.7) hr / 59 (11.7, 8.9C14.5) hr / 64 (13.3, 10.3C16.3) hr / 66 (15.1, 11.7C18.5) hr / 237 (11.2, 9.8C12.5) hr / Seasonal influenza serotype H1N1(pdm09)94 (13.4, 10.9C16.0)85 (16.8, 13.5C20.1)90 (18.7, 15.2C22.2)79 (18.1, 14.5C21.7)348 (16.4, 14.8C18.0) H3N2237 (33.9, 30.4C37.4)165 (32.6, 28.5C36.7)199 (41.4, 37.0C45.8)171 (39.1, 34.6C43.7)772 (36.3, 34.3C38.4) Open in a separate windowpane The seroprevalence profile was geographically distinct (Number 3). For example, in Shandong Province, H9N2 disease antibody seroprevalence was 23%, which was higher than in additional provinces, especially Sichuan Province, which experienced only a 4.2% seroprevalence for this subtype. Provinces in the Yangtze River Delta, which were the first to statement H7N9 infections in patients during the 2013 outbreak, exhibited higher seroprevalence rates compared with the additional provinces. Shanghai had a rate of 10.3% and Jiangsu Province experienced a rate of 6.9%. In Sichuan Province, where a nonClaboratory-confirmed H7N9-infected patient was reported before 2017, no participant tested positive for the H7N9 subtype. Open in a separate window Number 3 Avian influenza disease seroprevalence in the analyzed regions of China during December 2014CApril 2016. Rabbit Polyclonal to OR2AT4 A) Geographic areas included for serosurveillance: 1 municipality, Shanghai, and 6 provinces, Guangdong, Henan, Jiangsu, Jiangxi, Shandong, and Sichuan. B) Seroprevalence against avian influenza A disease subtypes in 4 cross-sectional studies. Colours on map correspond to colors in pub graphs. *Seasonal influenza disease subtype. Seroprevalence of H5 and H6 subtypes among poultry workers also were different by region. Detected H5 subtypes included H5N1-SH199 clade 220.127.116.11c in 5.3% of samples from Shandong Province; H5N1-SC29 clade 18.104.22.168 in 3.0% of samples from Jiangsu Province and in 3.3% of samples from Sichuan Province; and H5N6 in 4.9% of samples from Shanghai. We recognized H6N1 in 5.2% of samples from Jiangsu Province and in 3.8% from Shanghai and H6N6 in 3.3% of samples from Shanghai (Number 3). Among the 216 participants in the control group, we found no evidence of antibodies against H7N9 disease and a lower prevalence (3.7%) of antibodies against H9N2 disease than in the poultry workers. We observed no statistically significant LY 344864 LY 344864 variations in the prevalence of antibodies against additional AIV subtypes between the control group LY 344864 and poultry workers (Appendix Table 2). Seroconversion of Antibodies against AIVs among Poultry Workers We observed seroconversion in all AIV antigens during the study period, except the H10 subtype, which might represent a new asymptomatic AIV illness among poultry workers (Number 4, panel A). Among 652 poultry workers with combined or serial serum samples during the study, 3.5% shown seroconversion for H9N2 virus, 1.4% demonstrated seroconversion for H7N9 disease, and 1% demonstrated seroconversion for H5 or H6 viruses (Number 4, panels B and C; Appendix Furniture 3C9). Because we saw no evidence of H10N8 disease, we also saw no seroconversion for the subtype (Table 4; Number 4, panel A). Open in a separate window Number 4 Seroconversion and prolonged positivity for avian influenza disease (AIV) A subtypes based on HI titers inside a cohort study in China during December 2014CApril 2016. Each dot and collection connection represents 1 participant. Red dashed lines represent positive cutoff for the HI titers; HICpositive samples were confirmed by a microneutralization assay. A) Assessment of paired samples from participants during 2 monitoring periods showing seroconversion for 6 AIV subtypes. Weighted lines and dots symbolize participants with seroconversion. B) Variety of individuals with 2 positive test who had been seropositive for 6 persistently.